COMBINING HEPATIC PERCUTANEOUS PERFUSION WITH IPILIMUMAB PLUS NIVOLUMAB IN ADVANCED UVEAL MELANOMA (CHOPIN): STUDY PROTOCOL FOR A PHASE IB/RANDOMIZED PHASE II TRIAL

Abstract Background While immune checkpoint inhibition (ICI) has revolutionized the treatment of metastatic cutaneous melanoma, no standard treatments are available for patients with metastatic uveal melanoma (UM).Several locoregional therapies are effective in the treatment of liver metastases, such as percutaneous hepatic perfusion with melphalan

Estimation of division and death rates of lymphocytes in different conditions is vital for quantitative understanding of the immune system.Deuterium, in the form of deuterated glucose or heavy water, can be used to measure rates of proliferation and death of lymphocytes in vivo.Inferring these rates from labeling and delabeling curves has been subj

With the recent explosion in endocrine Solid Ink conferences, audience fatigue has set in and conference planners are now looking at newer pedagogic methods to revive the interest of audiences in these conferences.The endocrine quiz has finally come of vogue and is increasingly becoming one of the most popular attractions of any ranking endocrine c

This paper presents an approach to mathematical terms similar to the approach developed by Kripke in order to deal with natural kind terms; in fact, I argue that mathematical terms are natural kind terms in the sense Flash Light of Kripke.Thus, I suggest that, from a semantic perspective, such terms should be Rangefinder seen as primarily referring

Background The redundant extracellular matrix (ECM) within tumor microenvironment (TME) such as hyaluronic acid (HA) often impairs intratumoral dissemination of antitumor drugs.Oncolytic viruses (OVs) are being studied extensively for cancer therapy either alone or in conjunction with chemotherapy and immunotherapy.Here, we designed a novel recombi